Viagra

1. What is Viagra?
2. Generics
3. Dosage
4. Side Effects
5. Contraindications
6. Interactions
7. Viagra and Alcohol
8. Viagra History of Creation
9. Viagra and Pulmonary Hypertension
10. Viagra and Diabetes

What is Viagra?

Viagra is a medication produced for erectile dysfunction treatment. It becomes so reasonable for regular use for a different reason – because it has specific characteristics regarding its time of action.

The action of this drug is purely individual in accordance with man’s constitution, particularly of the digestive system and individual pills tolerability. Some representatives of the stronger sex reported feeling the effect for more than 4 hours. Others say that for them it is possible to observe the good effects even in the next morning. That is, Viagra operates individually for each man.

It is necessary to seriously consider how to take Viagra, to plan intimacy. For example, the drug is taken on an empty stomach or before meals. It will work faster and more efficiently than taking it immediately after meals. The reason for this is the stomach will be overloaded, and therefore pills will need much more time to dissolve and enter the blood flow. Find more details about Viagra.

Generics

Viagra generics are the most popular drugs that are sold in pharmacies.

Today you can find analogs under the following names: Sildenafil, Aphrodil/Edegra/Erasmo/Penegra/Revatio/Supra/Silagra/Zwagra and many others. But one thing unites all of them - identical active ingredient, i. e., these are generics (drugs with the same active ingredient as original, but much cheaper in cost).

You can buy Sildenafil online in My Canadian Pharmacy. Here you can find necessary drugs of high-quality at affordable prices. We offer not only Viagra and its generics, but also Cialis, Levitra, and other medications to treat erectile dysfunction in women and men.

The generic cost will pleasantly surprise you, it much lower than in other pharmacies. In our online pharmacy, Sildenafil has lots of positive reviews concerning its quality, price, effectiveness, side effects and also work of the pharmacy itself. These Sildenafil reviews will help you to make sure that this drug is the best and make the right choice without fears and doubts. If you are looking for cheap Sildenafil or some other generics, you found your destination point. My Canadian Pharmacy is what you need and even more. It is your friend and qualified guide in the world of affordable and quality medicine.

Dosage

Pills are taken orally with a glass of clean water. The average recommended dosage is 50 mg. Appropriate to this dosage pill is taken 1 hour before planned sexual activity. Average sildenafil dosage 50 mg can be reduced to 25 mg, and increased up to 100 mg, depending on tolerability and effect intensity. Maximum dosage should not exceed 100 mg.

Viagra should be taken one time a day, one hour before planned sexual intercourse. This pill should contain 25 mg, 50 mg or 100 mg of active substance. Elderly people can take sildenafil in the same dosages. When taken with meals sildenafil effect develops a little later than when applied on an empty stomach.

If vision or hearing deterioration suddenly appears, you should immediately stop using the drug. Sildenafil cannot be combined with other drugs that also eliminate erectile dysfunction. In general, the drug does not reduce attention and speed of psychomotor reactions, so during treatment with Sildenafil, you can drive cars and mechanisms. However, you must carefully monitor your own state, because the drug can cause a decrease in blood pressure, blurred vision and impaired color perception. High risk of these effects appears at early use of the drug or dosage change.

Overdose

When applying drug in high doses (up to 800 mg or more) Viagra overdose may appear. The higher the dose is taken – the more negative symptoms are likely to develop, and the stronger they are expressed. Overdose is manifested in:

• hot flashes;
• dizziness;
• facial redness;
• headaches;
• nasal congestion;
• vision impairment;
• decreased blood pressure;
• digestive disorders.

To treat overdose consequences various drugs are used that can eliminate negative symptoms.

Side Effects

In clinical studies, with individual selection of doses, the following adverse events occurred more often, the connection of which with the drug intake was possible, probable or unknown:

• cardiovascular – headaches, flushing, dizziness;
• digestion – dyspepsia;
• breathing – nasal congestion;
• sensory organs – vision changes (mild and transient, most often, changes in the color of objects, as well as an increased perception of light and blurred vision).

Clinical studies of side effects, which were conducted in different countries, involved more than 3700 patients (aged 19 to 87). More than 550 patients received treatment for more than one year. The tolerability was good. In placebo-controlled clinical trials, the frequency of therapy interruption because of adverse events was low and comparable to that of placebo. Adverse events were generally transient and mild or moderate in severity. In any design studies, nature of adverse events in patients treated with Viagra was similar. In studies with fixed doses frequency of adverse events increased when increasing dosage. In studies with a selection of dosage (such studies better reflect recommended application scheme), nature of adverse events was comparable to that in fixed-dose studies.

When using the drug in doses greater than recommended, adverse events were similar to those noted above, but they are usually more common.

Cases of priapism are not registered. Study the complete list of side effects.

Contraindications

Viagra is allowed to use, but under doctor’s supervision, if:

• patient has penis structure deformities (especially regarding tissues, is formed with);
• patient has hematopoiesis diseases (anemia of certain forms, leukemia and some other disease);
• frequently observed hemorrhages;
• gastrointestinal tract ulcers in an active phase;
• genetically caused pigmented retinitis;
• liver dysfunction, especially diseases that destroy liver tissue;
• kidney diseases, characterized by their poor functioning;
• too low or too high blood pressure;
• patients who had heart attacks or blood strokes should be careful when taking this drug;
• severe heart diseases;
• use of certain drugs.

Viagra is prohibited if a man has an idiosyncrasy to drug components, as well as when he is being treated with nitrates.

Get acquainted with a list of contraindications to Viagra.

Interactions

Knowing Viagra interactions with other drugs is very important fact, to be considered before buying this means. Everyone knows that it is able to improve the situation in intimate life of men suffering from erectile dysfunction. But people who have decided to take Viagra need to be informed about what can or vice versa cannot influence the drug action.

Violations of Viagra Clearance

Medics noticed that some drugs slow down its clearance rate from the body. When combined with such drugs, it took more time to completely rid the body of sildenafil. This is manifested in increased sildenafil concentration in blood for several hours or even days, which, in its turn, is associated with risk of undesirable side effects. These impact can be caused by:

• itraconazole and ketoconazole (commonly used to treat fungal infections);
• tagamet drug, which is used in tumors treatment;
• erythromycin antibiotic.

After careful study of this issue by experts of “Pfizer” company, Viagra use in combination with these and some other rare drugs was allowed, only the dosage should be minimal. It is recommended to use pills containing 25 mg of sildenafil. So, if you are constantly taking any medication, carefully read instructions to Viagra and, adjust dosage if necessary.

Viagra and Aspirin

There are some misconceptions about Viagra interaction with other frequently used drugs, such as aspirin. Some people mistakenly believe that the use may have an impact on aspirin action in the blood. Especially concerned were those who regularly use aspirin prevent cardiac angina. But this fear has long been dispelled by physicians. If medicines that you are taking are not mentioned in instructions to sildenafil, so these drugs can be well combined, they do not interact and does not interfere with each other… All about the interactions with other drugs.

Viagra and Alcohol

Viagra and alcohol compatibility is as important to consider as side effects and contraindications. No adverse effect on drug action and health joint use of this ED drug and alcohol does not have. This was proven by studies conducted by “Pfizer” company. Researchers observed men who have been drinking alcohol. One group used only alcohol and the other – together with Viagra. Alcohol affected the same way on body condition of men in both groups.

But do not forget that alcohol itself has a serious impact on the body and sexual abilities. On the one hand, this is a positive impact, as a man loosens up and becomes more responsive to passion. But on the other hand, alcohol in large doses is capable to influence human body state so much (up to poisoning by overdose), that magical effect is simply reduced to nothing.

So, Viagra is a drug, which means that if you want to achieve the maximal effect and not harm your health at the same time, you must carefully read instructions before using this ED drug and take into account all recommendations given there.

Viagra History of Creation

Its history of creation starts in 1992. Its development is the third greatest random achievement in medicine after X-rays and penicillin. Researchers who discovered properties of sildenafil were awarded the Nobel Prize in 1998. In 1992, in Sandwich (United Kingdom) “Pfizer” company conducted studies of a new drug – sildenafil citrate, which was intended to treat many heart problems.

Developers believed that sildenafil citrate would increase blood flow to heart muscle and lower blood pressure. However, during research, it was found that sildenafil citrate does not particularly affect blood flow in myocardium or blood pressure. Also, it was discovered that some male participants of the experiment were not willing to return the pills after tests. The reason for this was a sharp improvement in erectile function. Therefore, despite the insignificant influence of sildenafil on blood circulation in heart muscle, it caused enough blood flow to male genitals.

Researchers of pharmaceutical company “Pfizer” did not overlook such an unexpected property of sildenafil citrate and recognized in it a good remedy to treat erectile dysfunction. So there appeared Viagra drug, the name came from combining words “Vigor” (strength, power) and “Niagara” (Niagara Falls) – the most powerful waterfall in North America.

To confirm Viagra properties in 1993 there were conducted many clinical studies, so high efficiency and safety in treating erectile dysfunction were proven. In the end, the United States Food and Drug Administration has approved the use of this drug. Its effectiveness was tested on more than 3,000 men of all ages with erectile problems during up to 26 years, caused by mental, physical or mixed mental and physical factors.

Results of these studies have proved its effectiveness in restoring healthy erection and improving the performance of successful sexual intercourse in many patients, among them, the majority of diabetics, patients with spinal cord injury, other associated clinical conditions, and patients, who take many drugs at the same time… Learn more about history of Viagra creation.

Viagra and Pulmonary Hypertension

According to preliminary study results, many diseases, besides erectile dysfunction, can be treated with Viagra, and pulmonary hypertension is one of them.

In a study conducted on 16 patients with pulmonary fibrosis, it was discovered that sildenafil, sold under the trademark “Viagra”, reduces pressure in arteries supplying lungs. High pressure in these vessels, known as hypertension, may result in pulmonary fibrosis, an inflammation, which causes scarring of lungs. In patients with this pathology, lungs ability to deliver oxygen is sharply limited.

A new study allows suggesting that sildenafil, known for its vasodilating effect, can also reduce pressure in pulmonary arteries.

At present, for primary pulmonary hypertension treatment (not caused by pulmonary or cardiac diseases), vasodilator drug – epoprostenol is used. However, it requires continuous intravenous administration, which is inconvenient and increases the risk of infection. When pulmonary hypertension occurs due to pulmonary fibrosis, drugs that cause vasodilation in all the body can strengthen hypoxia, improving blood flow in affected parts of lungs.

According to authors of a new study, it is important to find a drug that is able to expand blood vessels in healthy areas of lungs and can be easily applied. To test their hypothesis about sildenafil effectiveness, Dr. Hossein Ardeschir Ghofrani and his colleagues from Justus-Liebig-University in Giessen, Germany, assigned to 16 patients with pulmonary fibrosis, suffering from severe pulmonary hypertension, treatment with sildenafil or epoprostenol. Before treatment, all patients did inhaled nitric oxide (NO), a strong vasodilator, normally present in the body.

It was found that all three substances reduced blood pressure in lungs, however, only sildenafil and NO acted specifically on pulmonary vessels. Patients taking epoprostenol general arterial blood pressure also and oxygen concentration in arteries decreased. As researchers say, they have decided to choose sildenafil because it enhances effects of NO by inhibiting the phosphodiesterase-5 enzyme which is intensively produced in lung tissue.

Despite the fact that this work must be confirmed by larger studies, unique properties of sildenafil suggest that the drug may be used for long-term treatment of secondary pulmonary hypertension with pulmonary fibrosis. Read interesting facts about using Viagra at Pulmonary Hypertension.

Viagra and Diabetes

Usually, doctors initially recommend the use of androgen therapy for impotence caused by diabetes treatment – replacement of male sex hormone with medications. This allows not only to improve potency but in general, has a positive effect on men’s health.

If this technique is not effective, then medication from phosphodiesterase-5 inhibitors group is prescribed. First on their list is well-known Viagra (sildenafil citrate).

This drug helps men in about 70% of cases. It does not lead to blood glucose level increase, but can cause some side effects:

• hot flushes;
• blurred vision and increased sensitivity to light;
• headaches;
• indigestion.

A repeated use can cause addictive effect and in this case possibility of adverse reactions is reduced.

Initial dosage is 50 mg but at diabetes, it can be increased to 100 mg. Viagra should be taken approximately one hour before sexual intercourse. After receiving erection occurs only in case of natural sexual excitement, the effect lasts up to six hours. Find all aspects of Viagra application at diabetes.